Left ventricular dysfunction in a cohort of new onset idiopathic inflammatory myopathy without known heart disease

Abstract Impaired myocardial function is linked to inflammatory mechanisms. Indeed, many systemic diseases are associated risk of developing heart disease. Idiopathic myopathy (IIM; here Dermato- or polymyositis) rare diseases, characterised by immune infiltration in muscle, presence autoantibodies and cytokines circulation leading weakness disability. IIM can involve extra-muscular tissues, e.g. heart, associ-ated with elevated for cardiovascular Heart little investigated has mostly been studied patients at a chronic stage concomitant To our knowledge, not characterized the early when cardiomyopathy may be high. Our hypothesis that early-stage present subclinical dysfunction detected echocardiography. We used echocardiography (echo) following clinical standards investigate cohort 18 (61% females; age 46±12 years) recent onset (mean diagnosis time 5 month). Patients were recruited from rheumatology clinic Karolinska University Hospital, Stockholm, had given written consent. None previous Echo parameters compared normal reference limits as established American Society Echocardiography. failure association (HFA)-PEFF score (≥2 p) was define left ventricular diastolic (LVDD). Ejection fraction (EF) generally preserved no patient displaying EF<55% (Table 1). Yet, 4 (22%) displayed reduced global strain (LVGLS; >−20%) suggesting impaired contraction. In contrast, seen several indicated one more outside rage (table Moreover, calculating HAVA-PEFF 9 (50%) fulfilled criteria LVDD. hypertension (>140/90 mmHg), hypertrophy. without known disease, we have found prevalent 50% fulfilling LVDD according HFA-PEFF score. This gives high likelihood EF (HFpEF). conclude important initial work up screen likely Funding Acknowledgement Type funding sources: Foundation. Main source(s): Swedish Lung Foundation